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Description
Phospho-NRF2 (Ser40) Recombinant Rabbit mAb (S-1720-97)Product Specification Host Rabbit Antigen Phospho NRF2 (Ser40) Synonyms Nuclear factor erythroid 2 related factor 2; NF E2 related factor 2; NFE2 related factor 2; Nrf 2; Nuclear factor; erythroid derived 2, like 2; NFE2L2 Immunogen Synthetic Peptide Location Nucleus Accession Q16236 Clone Number S 1720 97 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | Phospho-NRF2 (Ser40) |
| Synonyms | Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; Nuclear factor; erythroid derived 2, like 2; NFE2L2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q16236 |
| Clone Number | S-1720-97 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:250 | Hu |
| IHC-P | 1:500 | Hu |
Background
Phospho-NRF2 (Ser40) is a crucial form of the NRF2 protein, which is a basic leucine zipper transcription factor involved in regulating the antioxidant response. When phosphorylated at Ser40 by protein kinase C (PKC), NRF2 dissociates from its repressor KEAP1, leading to its nuclear translocation and activation. This activation results in the upregulation of antioxidant genes containing antioxidant response elements (AREs), helping cells combat oxidative stress. The phosphorylation of NRF2 at Ser40 is essential for its stability and function, and it plays a significant role in various cellular processes, including protection against oxidative damage and regulation of metabolic pathways.
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