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Description
IGF1 Receptor Recombinant Rabbit mAb (S-1617-146)Product Specification Host Rabbit Antigen IGF1 Receptor Synonyms Insulin like growth factor 1 receptor; Insulin like growth factor I receptor (IGF I receptor); CD221; IGF1R Immunogen Recombinant Protein Location Cell membrane Accession P08069 Clone Number S 1617 146 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample MCF7, A431, HepG2, HeLa, HCT 116, MDA MB 231, HEK 293, C2C12, NIH 3T3, mouse brain, mouse
Product Specification
| Host | Rabbit |
| Antigen | IGF1 Receptor |
| Synonyms | Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor (IGF-I receptor); CD221; IGF1R |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P08069 |
| Clone Number | S-1617-146 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | MCF7, A431, HepG2, HeLa, HCT 116, MDA-MB-231, HEK-293, C2C12, NIH/3T3, mouse brain, mouse spleen, C6, rat brain |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
The insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase that is widely expressed on the surface of human cells and plays a crucial role in cell growth, proliferation, and differentiation. It is activated by insulin-like growth factor 1 (IGF-1) and IGF-2, and to a lesser extent by insulin. The IGF-1R is structurally similar to the insulin receptor and consists of two extracellular α-subunits involved in ligand binding and two transmembrane β-subunits containing a tyrosine kinase domain. Upon activation, IGF-1R triggers several intracellular signaling pathways, including the PI3K/Akt/mTOR and RAS/RAF/MAPK pathways, which promote cell survival, inhibit apoptosis, and regulate metabolism. Additionally, IGF-1R has been found to migrate to the cell nucleus, where it can act as a transcriptional activator. Given its significant anti-apoptotic and pro-survival functions, IGF-1R is highly expressed in many types of cancer and is considered a promising target for cancer therapy.
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