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Description
VAMP2 Recombinant Rabbit mAb (S-2359-2)Product Specification Host Rabbit Antigen VAMP2 Synonyms Vesicle associated membrane protein 2; VAMP 2; Synaptobrevin 2; SYB2 Immunogen Synthetic Peptide Location Cell membrane Accession P63027 Clone Number S 2359 2 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample U 87 MG, SH SY5Y, mouse brain, PC 12, C6, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | VAMP2 |
| Synonyms | Vesicle-associated membrane protein 2; VAMP-2; Synaptobrevin-2; SYB2 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P63027 |
| Clone Number | S-2359-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | U-87 MG, SH-SY5Y, mouse brain, PC-12, C6, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Rt |
Background
VAMP2, also known as vesicle - associated membrane protein 2，is a key protein in the SNARE complex，which plays a crucial role in the process of membrane fusion and neurotransmitter release in neurons. It is mainly located on the synaptic vesicle membrane and interacts with other SNARE proteins such as syntaxin - 1 and SNAP - 25 on the presynaptic membrane to form a stable SNARE complex. This complex drives the fusion of the synaptic vesicle membrane with the presynaptic membrane，thereby promoting the release of neurotransmitters into the synaptic cleft，which is essential for the transmission of nerve signals. Mutations or dysfunction of VAMP2 can lead to neurological disorders，highlighting its importance in maintaining normal neural function.
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